This Japanese patent is the follow on to issued US patent number 9,193,664 that covers new and more efficient methods of improving crystallization outcomes for compounds used in the food, pharmaceutical, medical nutrition, nutraceutical, cosmetic, agricultural, fine chemicals, and bioengineering fields. Early adopters in pharmaceutical R&D and specialty Contract Research Organizations (CROs) stand to benefit substantially as the crystallization of small molecule Active Pharmaceutical Ingredients (APIs) remains a challenging early step in drug development.