As part of a Phase II SBIR award from the National Institutes of Health to DeNovX, a strategic partnership has been formalized between DeNovX and the X-ray Sciences Division at Argonne National Laboratory, which is operated by The University of Chicago for the United States Department of Energy. The goal of this work is to improve the solubility and bioavailability of small molecule active pharmaceutical ingredients and cocrystals by developing new high throughput screening discovery techniques that can fully leverage the analytical capabilities of synchrotron X-ray powder diffraction.